Dr. Ana Quaglio, head of R&D at Verum Ingredients, has co-authored a peer-reviewed scientific publication on the participation of miRNAs in celiac disease. It is the most prevalent gastrointestinal disease worldwide and is commonly known as “gluten intolerance”. In genetically susceptible individuals, ingestion of wheat gluten and similar proteins in rye and barley, induces an immune-mediated response that results in inflammation and damages the small intestinal mucosa.

“Gluten” is a term commonly used to refer to specific disease-activating proteins present in wheat (Triticum spp.), barley (Horderum vulgare), and rye (Secale cereale). However, gluten is the storage protein fraction present only in wheat grains. Oats are normally inoffensive to individuals with celiac disease, but cross-contamination with other cereals during its processing and storage is commonly observed; therefore, it is recommended to avoid it.

MicroRNAs are a class of small RNA molecules that can silence multiple target genes and can control approximately 30% of gene expression thereby upregulating or downregulating the expression of specific genes in the human body.

Our review shows that miRNA expression can suppress or stimulate pathways related to celiac disease pathogenesis by regulating basic cellular functions, such as cell proliferation and differentiation, immune response, and activation of the inflammatory cascade. Further studies with celiac disease patients should be performed to determine the potential use of miRNAs in celiac disease treatment.

“Co-authoring this peer-reviewed publication gave me the opportunity to develop a deeper understanding of the interplay between the food that we eat and our overall health. Celiac disease is a good example of how our diet, microbiome and immune system are interconnected. I am confident in applying these insights to our internal R&D programs at Verum Ingredients.”, says Dr. Ana Quaglio.

Reference:

Rigo FF, Oliveira ECS, Quaglio AEV, Moutinho BD, Di Stasi LC, Sassaki LY. Expression of MicroRNAs in Adults with Celiac Disease: A Narrative Review. Int J Mol Sci. 2024 Aug 30;25(17):9412.

Access the complete article at https://www.mdpi.com/1422-0067/25/17/9412